Sipa1l1 Gene Summary [Rat]
Enables actin filament binding activity; protein kinase binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including activation of GTPase activity; postsynaptic actin cytoskeleton organization; and regulation of postsynapse organization. Located in dendritic spine; neuronal cell body; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sipa1l1 |
| Official Name | signal-induced proliferation-associated 1 like 1 [Source:RGD Symbol;Acc:708497] |
| Ensembl ID | ENSRNOG00000007646 |
| Bio databases IDs | |
| Aliases | signal-induced proliferation-associated 1 like 1 |
| Synonyms | 4931426N11RIK, AW213287, E6TP1, KIAA0440, LOC102724024, LOC283567, mKIAA0440, signal-induced proliferation-associated 1 like 1, SPA1, SPAL, Spar, SPAR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sipa1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin regulatory domain
- ubiquitin protein ligase binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- guanylate kinase binding domain
- canonical PDZ domain
- ephrin receptor binding
- coiled-coil domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- PDZ domain
- Rap/ran-GAP
- actin filament binding
- actin-binding domain
- binding protein
- C-terminal domain of SPAR protein
- Cell division protein ZapB
Pathways
Biological processes and signaling networks where the Sipa1l1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- breast cancer
- neurotic disorder
- neuroticism
- seizures
- sedation
- pulmonary edema
- myocardial infarction
- osteosarcoma
- osteosarcomagenesis
role in cell
- expression in
- proliferation
- activation in
- apoptosis
- length
- migration
- organization
- morphology
- size
- localization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- postsynaptic region
- actin cytoskeleton
- Plasma Membrane
- cytosol
- dendritic spines
- postsynaptic spines
- perikaryon
- dendrites
- postsynaptic density
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sipa1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- regulation of axonogenesis
- regulation of small GTPase mediated signal transduction
- ephrin receptor signaling pathway
- regulation of GTPase activity
- regulation of synaptic plasticity
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- dendritic spine
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- ephrin receptor binding