Sftpa1 Gene Summary [Rat]
Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space and multivesicular body. Biomarker of asthma; congenital diaphragmatic hernia; lung disease (multiple); and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to human SFTPA1 (surfactant protein A1) and SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sftpa1 |
| Official Name | surfactant protein A1 [Source:RGD Symbol;Acc:3665] |
| Ensembl ID | ENSRNOG00000011438 |
| Bio databases IDs | |
| Aliases | surfactant protein A1 |
| Synonyms | LOC100364823, LOC100912884, LOC102557073, LOC108348361, PSAP, PSP-A, Sftp-1, Sftpa, Sftpl, SP-A, Surfactant Apoprotein, surfactant associated protein A1, surfactant protein A1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sftpa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- collagen-like domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- Lectin C-type domain
- Collagen triple helix repeat (20 copies)
- neck domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pneumonia
- eosinophilia
- sepsis
- respiratory distress syndrome
- infection by Orthomyxoviridae
- infection by bacteria
role in cell
- formation
- expression in
- quantity
- growth
- killing
- cell viability
- proliferation
- number
- abnormal morphology
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- alveolar epithelial lamellar bodies
- multivesicular bodies