Aoc1 Gene Summary [Rat]
Enables putrescine oxidase activity. Predicted to be involved in putrescine metabolic process. Located in bicellular tight junction. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aoc1 |
| Official Name | amine oxidase, copper containing 1 [Source:RGD Symbol;Acc:61296] |
| Ensembl ID | ENSRNOG00000008575 |
| Bio databases IDs | |
| Aliases | amine oxidase, copper containing 1 |
| Synonyms | ABP, ABP1, Amiloride binding, amine oxidase copper containing 1, amine oxidase, copper containing 1, DAO, DAO1, HISTAMINASE, KAO, KDAO, Kidney amine oxidase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aoc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Copper amine oxidase, N3 domain
- amine oxidase
- diamine oxidase
- calcium ion binding
- enzyme
- protein binding
- Copper amine oxidase, N2 domain
- copper ion binding
- Copper amine oxidase, enzyme domain
- amine oxidase (copper-containing)
- protein homodimerization
- putrescine oxidase
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- prostate cancer
- primary ovarian cancer
- non-insulin-dependent diabetes mellitus
- gout
- metabolic syndrome X
- colon cancer
- carpal tunnel syndrome
- weight gain
regulates
- reactive oxygen species
- putrescine
- histamine
- PRKN
role in cell
- growth
- production in
- proliferation
- migratory capacity
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- cellular membrane
- Plasma Membrane
- tight junctions
- specific granules
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aoc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amine metabolic process
- response to antibiotic
- putrescine metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- extracellular space
- tight junction
- extracellular vesicular exosome
- specific granule lumen
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- primary amine oxidase activity
- heparin binding
- methylputrescine oxidase activity
- putrescine oxidase activity
- propane-1,3-diamine oxidase activity
- diamine oxidase activity
- histamine oxidase activity
- protein binding
- quinone binding
- copper ion binding
- calcium ion binding