Sox15 Gene Summary [Rat]

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of G0 to G1 transition; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within myoblast development; negative regulation of striated muscle tissue development; and skeletal muscle tissue regeneration. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Sox15
Official Name
SRY-box transcription factor 15 [Source:RGD Symbol;Acc:1312022]
Ensembl ID
ENSRNOG00000012155
Bio databases IDs NCBI: 363632 Ensembl: ENSRNOG00000012155
Aliases SRY-box transcription factor 15
Synonyms Sox16, SOX20, SOX26, SOX27, SRY-box transcription factor 15, SRY (sex determining region Y)-box 15
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sox15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • transcription regulator
  • double-stranded DNA binding
  • nucleic acid binding
  • high mobility group (HMG)-box domain superfamily
  • HMG (high mobility group) box
  • HMG-box domain
  • high mobility group
  • chromatin binding
  • protein binding
  • sequence-specific DNA binding
  • DNA binding

Pathways

Biological processes and signaling networks where the Sox15 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
regulated by
regulates
role in cell
  • expression in
  • cell viability
  • differentiation
  • proliferation
  • morphology
  • number
  • development

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • Cytoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Sox15 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • male gonad development
  • neuron differentiation
  • regulation of transcription, DNA-dependent
  • brain development
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin organization
  • negative regulation of striated muscle tissue development
  • myoblast development
  • skeletal muscle tissue regeneration
  • regulation of transcription from RNA polymerase II promoter
  • negative regulation of transcription from RNA polymerase II promoter
  • trophoblast giant cell differentiation
  • positive regulation of satellite cell activation involved in skeletal muscle regeneration
  • cell differentiation
  • positive regulation of myoblast proliferation
  • positive regulation of G0 to G1 transition

Cellular Component

Where in the cell the gene product is active
  • transcription factor complex
  • nucleus
  • cytoplasm
  • chromatin

Molecular Function

What the gene product does at the molecular level
  • DNA binding
  • sequence-specific DNA binding transcription factor activity
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • chromatin binding
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

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