Aebp2 Gene Summary [Rat]
Predicted to enable transcription coregulator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of ESC/E(Z) complex. Orthologous to human AEBP2 (AE binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aebp2 |
| Official Name | AE binding protein 2 [Source:RGD Symbol;Acc:1307233] |
| Ensembl ID | ENSRNOG00000008929 |
| Bio databases IDs | |
| Aliases | AE binding protein 2 |
| Synonyms | AE binding protein 2, AI586002, AU023766, B230313N05Rik, Image:5356616 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aebp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Zinc-finger double domain
- transcription cofactor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- tricuspid valve disorder
- chronic mountain sickness
- infection by HIV-1
regulates
- synthetic promoter
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
- reporter gene
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- insoluble fractions
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aebp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- ESC/E(Z) complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription cofactor activity
- metal ion binding