Anp32b Gene Summary [Rat]
Predicted to enable RNA polymerase binding activity and histone binding activity. Involved in negative regulation of apoptotic process; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ANP32B (acidic nuclear phosphoprotein 32 family member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anp32b |
| Official Name | acidic nuclear phosphoprotein 32 family member B [Source:RGD Symbol;Acc:621285] |
| Ensembl ID | ENSRNOG00000009266 |
| Bio databases IDs | |
| Aliases | acidic nuclear phosphoprotein 32 family member B |
| Synonyms | 2410015B15Rik, acidic nuclear phosphoprotein 32 family member B, APRIL, BM554099, PAL31, PHAPI2, PHAPI2A, SSP29 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anp32b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- occurring C-terminal to leucine-rich repeats
- enzyme binding
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- chronic myeloid leukemia
- dilation of ureter
- cleft palate
- colon adenocarcinoma
- colon epithelial cancer
- megacolon
- atelectasis
- idiopathic pulmonary fibrosis
role in cell
- proliferation
- differentiation
- apoptosis
- expression in
- migration
- transactivation in
- assembly
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anp32b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- positive regulation of protein export from nucleus
- inner ear development
- negative regulation of cell differentiation
- vasculature development
- palate development
- regulation of apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- protein binding
- histone binding