ANP32B Gene Summary [Human]
Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ANP32B |
| Official Name | acidic nuclear phosphoprotein 32 family member B [Source:HGNC Symbol;Acc:HGNC:16677] |
| Ensembl ID | ENSG00000136938 |
| Bio databases IDs | |
| Aliases | acidic nuclear phosphoprotein 32 family member B, acidic protein rich in leucines |
| Synonyms | 2410015B15Rik, acidic nuclear phosphoprotein 32 family member B, APRIL, BM554099, PAL31, PHAPI2, PHAPI2A, SSP29 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANP32B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- occurring C-terminal to leucine-rich repeats
- enzyme binding
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- chronic myeloid leukemia
- dilation of ureter
- cleft palate
- colon adenocarcinoma
- colon epithelial cancer
- megacolon
- atelectasis
- idiopathic pulmonary fibrosis
role in cell
- proliferation
- differentiation
- apoptosis
- expression in
- migration
- transactivation in
- assembly
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANP32B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- positive regulation of protein export from nucleus
- inner ear development
- negative regulation of cell differentiation
- vasculature development
- palate development
- regulation of apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- protein binding
- histone binding