Pdzd8 Gene Summary [Rat]
Predicted to enable lipid binding activity and metal ion binding activity. Predicted to be involved in several processes, including mitochondrial calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and regulation of cell morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdzd8 |
| Official Name | PDZ domain containing 8 [Source:RGD Symbol;Acc:1308622] |
| Ensembl ID | ENSRNOG00000009460 |
| Bio databases IDs | |
| Aliases | PDZ domain containing 8 |
| Synonyms | A630041P07Rik, IDDADF, PDZ domain containing 8, PDZK8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdzd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase C conserved region 1 (C1 domain) superfamily
- canonical PDZ domain
- coiled-coil domain
- protein binding
- PDZ domain
- synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum mitochondria contact site
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdzd8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- regulation of cell morphogenesis
- cytoskeleton organization
- mitochondrial calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrion
- membrane
- ER-mitochondrion membrane contact site
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- lipid binding