Tmem9b Gene Summary [Rat]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; salivary gland development; and sensory epithelium regeneration. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human ASCL3 (achaete-scute family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem9b |
| Official Name | TMEM9 domain family, member B [Source:RGD Symbol;Acc:1310775] |
| Ensembl ID | ENSRNOG00000013591 |
| Bio databases IDs | |
| Aliases | TMEM9 domain family, member B |
| Synonyms | 2310004K06RIK, C11ORF15, D7H11orf15, ICRFP703B1614Q5.3, RGD1310775, TMEM9 domain family member B, TMEM9 domain family, member B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem9b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TMEM9
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem9b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding