Cpa1 Gene Summary [Rat]
Enables exopeptidase activity. Involved in proteolysis involved in protein catabolic process and response to cadmium ion. Predicted to be active in extracellular space. Orthologous to human CPA1 (carboxypeptidase A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpa1 |
| Official Name | carboxypeptidase A1 [Source:RGD Symbol;Acc:2388] |
| Ensembl ID | ENSRNOG00000010725 |
| Bio databases IDs | |
| Aliases | carboxypeptidase A1 |
| Synonyms | 0910001L12Rik, Carboxypeptidase A, Carboxypeptidase a1, carboxypeptidase A1, pancreatic, CPA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc carboxypeptidase
- Zn_pept domain
- peptidase
- metallocarboxypeptidase
- protein binding
- carboxypeptidase A
- M14 family of metallocarboxypeptidases and related proteins
- exopeptidase
- Carboxypeptidase activation peptide
Pathways
Biological processes and signaling networks where the Cpa1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic cancer
- non-insulin-dependent diabetes mellitus
- hereditary pancreatitis
- preeclampsia
- hereditary chronic pancreatitis
role in cell
- survival
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- granules
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene metabolic process
- proteolysis
- response to cadmium ion
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metallocarboxypeptidase activity