Chrnb3 Gene Summary [Rat]
Enables acetylcholine binding activity. Contributes to heterocyclic compound binding activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrnb3 |
| Official Name | cholinergic receptor nicotinic beta 3 subunit [Source:RGD Symbol;Acc:621544] |
| Ensembl ID | ENSRNOG00000012448 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic beta 3 subunit |
| Synonyms | 5730417K16Rik, Acrb3, beta3 ACHR, beta3 NACHR, cholinergic receptor nicotinic beta 3 subunit, cholinergic receptor, nicotinic, beta polypeptide 3, cholinergic receptor nicotinic β 3 subunit, cholinergic receptor, nicotinic, β polypeptide 3, nAChR beta3, Nicotinic acetylcholine receptor β 3 subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrnb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- neurotransmitter receptor
- binding protein
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- acetylcholine binding
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrnb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- stroke
- lung adenocarcinoma formation
- pelvic pain
- psychomotor agitation
- Alzheimer disease
- postoperative pain
- treatment pain
- nicotine dependence
- morbid obesity
- disorder of diaphragm
regulated by
- ethanol
- NRG (family)
- nicotine
- Alpha Conotoxin M2
- acetylcholine
- decitabine
- PRKCE
- atracurium
- vecuronium
- arecoline
regulates
- dopamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synaptosomes
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrnb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- ion transmembrane transport
- response to nicotine
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- membrane
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- channel activity
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity
- acetylcholine binding