Prkce Gene Summary [Rat]
Enables several functions, including SH3 domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein serine/threonine kinase binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Located in Golgi membrane and T-tubule. Is active in glutamatergic synapse; neuromuscular junction; and presynaptic cytosol. Used to study hypertension. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkce |
| Official Name | protein kinase C, epsilon [Source:RGD Symbol;Acc:61925] |
| Ensembl ID | ENSRNOG00000015603 |
| Bio databases IDs | |
| Aliases | protein kinase C, epsilon |
| Synonyms | 5830406C15RIK, nPKC-epsilon, nPKC-ε, PKCE, PKC[e], PKC epsilon, PKC ε, protein kinase C epsilon, protein kinase C, epsilon, protein kinase C ε, protein kinase C, ε |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prkce often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- receptor activator
- V1 region
- C1A domain
- V domain
- Protein kinase domain
- enzyme activator activity
- cleavage site
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- alcohol group acceptor phosphotransferase
- protein kinase C
- variable domain 3
- Tyrosine kinase, catalytic domain
- C2 domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- autoinhibitory protein domain
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- calcium independent protein kinase C
- protein binding
- receptor binding
- SH3-domain binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- actin monomer binding
- pseudosubstrate domain
- C1B domain
- zinc finger domain
- Protein kinase C conserved region 2 (CalB)
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Prkce gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Amyloid Processing
- Apelin Endothelial Signaling Pathway
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- ErbB4 Signaling
- Fc Epsilon RI Signaling
- fMLP Signaling in Neutrophils
- Glioma Signaling
- Growth Hormone Signaling
- Gαq Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Mechanisms of Viral Exit from Host Cells
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- cancer
- epithelial cancer
- abdominal cancer
- tumorigenesis
- insulin resistance
role in cell
- proliferation
- differentiation
- quantity
- signaling in
- cell death
- activation in
- migration
- survival
- expression in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- soluble fraction
- membrane fraction
- glutaminergic synapse
- microtubule marginal band
- intermediate filament cytoskeleton
- intracellular membrane-bounded organelle
- intracellular compartment
- cytoskeleton
- cell borders
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cell-cell contacts
- cytosol
- proplatelets
- Golgi membrane
- neuromuscular junctions
- neurites
- nerve ending
- sarcolemma
- cytoplasmic vesicles
- transverse tubules
- cellular protrusions
- motor endplates
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prkce gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of cellular glucuronidation
- locomotory exploration behavior
- positive regulation of synaptic transmission, GABAergic
- insulin secretion
- macrophage activation involved in immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- Fc-gamma receptor signaling pathway involved in phagocytosis
- protein phosphorylation
- cellular response to prostaglandin E stimulus
- cell division
- regulation of peptidyl-tyrosine phosphorylation
- MAPK cascade
- apoptotic process
- positive regulation of cell-substrate adhesion
- positive regulation of epithelial cell migration
- cellular response to hypoxia
- negative regulation of protein ubiquitination
- establishment of localization in cell
- positive regulation of insulin secretion
- negative regulation of sodium ion transmembrane transporter activity
- intracellular signal transduction
- positive regulation of cytokinesis
- positive regulation of lipid catabolic process
- positive regulation of wound healing
- signal transduction
- response to morphine
- positive regulation of MAPK cascade
- cellular response to ethanol
- regulation of release of sequestered calcium ion into cytosol
- mucus secretion
- positive regulation of actin filament polymerization
- lipopolysaccharide-mediated signaling pathway
- TRAM-dependent toll-like receptor 4 signaling pathway
- positive regulation of mucus secretion
- cell-substrate adhesion
- synaptic transmission, GABAergic
- peptidyl-serine phosphorylation
- positive regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- synapse
- plasma membrane
- nucleus
- perinuclear region of cytoplasm
- intermediate filament cytoskeleton
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- cell periphery
Molecular Function
What the gene product does at the molecular level
- ethanol binding
- protein kinase activity
- enzyme activator activity
- protein serine/threonine kinase activity
- protein kinase C activity
- actin monomer binding
- calcium-independent protein kinase C activity
- ATP binding
- receptor activator activity
- protein binding
- metal ion binding
- 14-3-3 protein binding
- enzyme binding