Ppwd1 Gene Summary [Rat]
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in nuclear body. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPWD1 (peptidylprolyl isomerase domain and WD repeat containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppwd1 |
| Official Name | peptidylprolyl isomerase domain and WD repeat containing 1 [Source:RGD Symbol;Acc:1310204] |
| Ensembl ID | ENSRNOG00000012505 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase domain and WD repeat containing 1 |
| Synonyms | 4632422M10RIK, A330090G21Rik, KIAA0073, peptidylprolyl isomerase domain and WD repeat containing 1, RGD1310204 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppwd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- cyclophilin
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- WD domain, G-beta repeat
- cyclosporin A binding
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppwd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein peptidyl-prolyl isomerization
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nuclear body
- catalytic step 2 spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity