Nup58 Gene Summary [Rat]
Enables identical protein binding activity and nuclear localization sequence binding activity. A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport and regulation of protein import into nucleus. Located in nuclear envelope. Part of nuclear pore. Orthologous to human NUP58 (nucleoporin 58). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup58 |
| Official Name | nucleoporin 58 [Source:RGD Symbol;Acc:631334] |
| Ensembl ID | ENSRNOG00000012644 |
| Bio databases IDs | |
| Aliases | nucleoporin 58 |
| Synonyms | 1700017F11Rik, KIAA0410, mKIAA0410, nucleoporin 58, NUP45, NUP58/NUP45, NUPL1, p58/p45, PRO2463 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mechanosensitive ion channel porin domain
- binding protein
- structural constituent of nuclear pore
- protein binding
- nuclear localization sequence binding
- identical protein binding
- Nucleoporin FG repeated region
Pathways
Biological processes and signaling networks where the Nup58 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear pores
- inner nuclear membrane
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- regulation of protein import into nucleus
- protein transport
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of nuclear pore
- nuclear localization sequence binding