Bcar1 Gene Summary [Rat]
Enables protein domain specific binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to endothelin; and cellular response to nitric oxide. Located in focal adhesion. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcar1 |
| Official Name | BCAR1 scaffold protein, Cas family member [Source:RGD Symbol;Acc:2406] |
| Ensembl ID | ENSRNOG00000019253 |
| Bio databases IDs | |
| Aliases | BCAR1 scaffold protein, Cas family member |
| Synonyms | BCAR1 scaffold protein, Cas family member, breast cancer anti-estrogen resistance 1, CAS, CAS1, CASS1, CRKAS, LOC100131601, P130CAP, P130CAS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- substrate domain
- Src binding domain
- protein kinase binding
- catalytic domain
- caspase cleavage site
- protein domain specific binding
- enzyme
- protein binding
- polyproline motif
- proline rich domain
- Src Homology 3 domain superfamily
- FAT-like_CAS_C
- YXXP domain
- serine-rich region
- YDXP motif
- SR domain
- helix-loop-helix domain
- PR domain
- Serine_rich_CAS
- Serine rich protein interaction domain
- tyrosine phosphorylation site
- Crk-Associated Substrate C-terminal domain
Pathways
Biological processes and signaling networks where the Bcar1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Axonal Guidance Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Ephrin A Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Integrin Signaling
- Leukocyte Extravasation Signaling
- Paxillin Signaling
- PTEN Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic epithelial cancer
- metastasis
- diabetes mellitus
- breast carcinoma
- pancreatic carcinoma
- open-angle glaucoma
- hereditary breast and/or ovarian cancer
- diffuse systemic sclerosis
- growth failure
role in cell
- expression in
- transformation
- growth
- binding in
- proliferation
- number
- formation in
- migration
- apoptosis
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- ruffle
- cell periphery
- perinuclear region
- cellular membrane
- focal adhesions
- podosomes
- actin cytoskeleton
- membrane skeleton
- Plasma Membrane
- cytosol
- apical cytoplasm
- growth cone
- neurites
- axons
- lamellipodia
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- actin filament organization
- platelet-derived growth factor receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of apoptotic process
- cell adhesion
- cell chemotaxis
- cell division
- hepatocyte growth factor receptor signaling pathway
- nerve growth factor receptor signaling pathway
- antigen receptor-mediated signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- integrin-mediated signaling pathway
- regulation of cell growth
- cellular response to hepatocyte growth factor stimulus
- positive regulation of endothelial cell migration
- cell migration
- T cell receptor signaling pathway
- positive regulation of cell migration
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- ruffle
- actin cytoskeleton
- cytosol
- axon
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- SH3 domain binding