Bloc1s2 Gene Summary [Rat]
Predicted to enable gamma-tubulin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in centrosome and recycling endosome. Orthologous to human BLOC1S2 (biogenesis of lysosomal organelles complex 1 subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bloc1s2 |
| Official Name | biogenesis of lysosomal organelles complex-1, subunit 2 [Source:RGD Symbol;Acc:1306551] |
| Ensembl ID | ENSRNOG00000012684 |
| Bio databases IDs | |
| Aliases | biogenesis of lysosomal organelles complex-1, subunit 2 |
| Synonyms | 2410089B13Rik, biogenesis of lysosomal organelles complex 1 subunit 2, biogenesis of lysosomal organelles complex-1, subunit 2, Bloc1s2a, BLOS2, BORCS2, CEAP, CEAP11, RSEP1, Sep1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bloc1s2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- protein binding
- Biogenesis of lysosome-related organelles complex-1 subunit 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- Mitochondria
- cytosol
- recycling endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bloc1s2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- platelet dense granule organization
- organelle transport along microtubule
- melanosome organization
- regulation of endosome size
- anterograde axon cargo transport
- neuron projection development
- endosomal transport
- induction of apoptosis via death domain receptors
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- BLOC-1 complex
- centrosome
- mitochondrion
- cytosol
- gamma-tubulin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- gamma-tubulin binding