Vps33b Gene Summary [Rat]
Predicted to be involved in several processes, including megakaryocyte development; skin morphogenesis; and vesicle organization. Predicted to act upstream of or within collagen fibril organization; collagen metabolic process; and peptidyl-lysine hydroxylation. Is active in synaptic vesicle. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; arthrogryposis, renal dysfunction, and cholestasis 1; cholestasis; kidney disease; and progressive familial intrahepatic cholestasis. Orthologous to human VPS33B (VPS33B late endosome and lysosome associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps33b |
| Official Name | VPS33B, late endosome and lysosome associated [Source:RGD Symbol;Acc:620644] |
| Ensembl ID | ENSRNOG00000013149 |
| Bio databases IDs | |
| Aliases | VPS33B, late endosome and lysosome associated |
| Synonyms | KDIDAR, PFIC12, vacuolar protein sorting 33B, VPS33B late endosome and lysosome associated, VPS33B, late endosome and lysosome associated |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps33b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- Sec1 family
- transporter
Pathways
Biological processes and signaling networks where the Vps33b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- arthrogryposis, renal dysfunction, and cholestasis type 1
- arthrogryposis, renal dysfunction, cholestasis
- hereditary disorder
- preeclampsia
- restless legs syndrome
- pain
- non-insulin-dependent diabetes mellitus
- keratoderma-ichthyosis-deafness syndrome
- metabolic syndrome X
- progressive familial intrahepatic cholestasis type 12
regulated by
- 2,4,5,2',4',5'-hexachlorobiphenyl
- PAGA
- YAP1
role in cell
- proliferation
- growth
- fusion
- quantity
- secretion
- localization
- differentiation
- organization
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- endosomes
- lysosome
- Golgi Apparatus
- cytosol
- lysosome membrane
- endosomal membrane
- alpha granules
- synaptic vesicles
- late endosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vps33b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- endosome organization
- intracellular transport
- protein transport
- regulation of platelet aggregation
- phagosome-lysosome fusion
- endosome to lysosome transport
- intracellular protein transport
- skin morphogenesis
- lysosome localization
- vesicle-mediated transport
- peptidyl-lysine hydroxylation
- megakaryocyte development
- melanosome localization
- collagen fibril organization
- platelet alpha granule organization
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule
- CORVET complex
- late endosome
- Golgi apparatus
- lysosomal membrane
- lysosome
- early endosome membrane
- late endosome membrane
- perinuclear region of cytoplasm
- endosome
- cytoplasm
- cytosol
- endosome membrane
- recycling endosome
- clathrin-coated vesicle
- HOPS complex
Molecular Function
What the gene product does at the molecular level
- protein binding