Cwc27 Gene Summary [Rat]
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cwc27 |
| Official Name | CWC27 spliceosome associated cyclophilin [Source:RGD Symbol;Acc:1310697] |
| Ensembl ID | ENSRNOG00000013252 |
| Bio databases IDs | |
| Aliases | CWC27 spliceosome associated cyclophilin |
| Synonyms | 3110009E13Rik, CWC27 spliceosome associated cyclophilin, CWC27 spliceosome-associated protein, NY-CO-10, RPSKA, SDCCAG-10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cwc27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diverticular disease
- diverticulitis
- inguinal hernia
- refractive error
- retinitis pigmentosa with or without skeletal anomalies
- bladder carcinoma
- retinal dystrophy
- schizophrenia
- retinitis pigmentosa with skeletal anomalies
- osteoarthritis
regulated by
- Complement component 1
- NOMO
role in cell
- growth
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cwc27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein folding
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- catalytic step 2 spliceosome
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity