Pth2r Gene Summary [Rat]
Enables parathyroid hormone receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and positive regulation of cold-induced thermogenesis. Predicted to be active in plasma membrane. Orthologous to human PTH2R (parathyroid hormone 2 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pth2r |
| Official Name | parathyroid hormone 2 receptor [Source:RGD Symbol;Acc:620612] |
| Ensembl ID | ENSRNOG00000015259 |
| Bio databases IDs | |
| Aliases | parathyroid hormone 2 receptor |
| Synonyms | parathyroid hormone 2 receptor, PTHR2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pth2r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- protein binding
- parathyroid hormone receptor
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- primary osteoporosis
- postmenopausal osteoporosis
- chronic kidney disease mineral and bone disorder
- glucocorticoid induced osteoporosis
- chronic hypoparathyroidism
- lung carcinoma
- lung carcinoma process
- heart disease
- idiopathic scoliosis
regulated by
- beta-estradiol
- PTH
- aldosterone
- peptide
- PTHLH
regulates
- cyclic AMP
- Ca2+
- RAMP3
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pth2r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- protein binding
- parathyroid hormone receptor activity
- peptide hormone binding