Jak1 Gene Summary [Rat]
Enables CCR5 chemokine receptor binding activity and growth hormone receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of homotypic cell-cell adhesion; and positive regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to be located in cytoplasm and nucleus. Predicted to be part of receptor complex. Predicted to be active in cytoplasmic side of plasma membrane and cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Biomarker of sciatic neuropathy and transient cerebral ischemia. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human JAK1 (Janus kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jak1 |
| Official Name | Janus kinase 1 [Source:RGD Symbol;Acc:69056] |
| Ensembl ID | ENSRNOG00000011157 |
| Bio databases IDs | |
| Aliases | Janus kinase 1 |
| Synonyms | AA960307, AIIDE, BAP004, C130039L05Rik, JAK1A, JAK1B, Janus kinase 1, JTK3, LOC105378775 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Jak1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- ATP-binding domain
- Jak Homology domain
- protein-tyrosine kinase
- Protein kinase domain
- FERM domain
- receptor binding domain
- Src homology 2 (SH2) domain
- loop domain
- FERM domain B-lobe
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- Band 4.1 homologues
- Protein kinase (unclassified specificity)
- JH2 domain
- catalytic domain
- SH2 like domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- kinase-like domain
- non-membrane spanning protein tyrosine kinase
- FERM F1 ubiquitin-like domain
- protein binding
- Pleckstrin homology-like domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Jak1 pleckstrin homology-like domain
- tyrosine kinase domain
- active site
- growth hormone receptor binding
Pathways
Biological processes and signaling networks where the Jak1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- CNTF Signaling
- EGF Signaling
- Glucocorticoid Receptor Signaling
- IGF-1 Signaling
- IL-17A Signaling in Airway Cells
- IL-2 Signaling
- IL-22 Signaling
- IL-3 Signaling
- IL-9 Signaling
- iNOS Signaling
- Insulin Receptor Signaling
- Interferon Signaling
- JAK/Stat Signaling
- Oncostatin M Signaling
- Pancreatic Adenocarcinoma Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- SPINK1 General Cancer Pathway
- Th1 Pathway
- Th2 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- liver cancer
- mixed phenotype acute leukemia
- rheumatoid arthritis
- ulcerative colitis
- advanced non-small cell lung cancer
- post polycythemia vera myelofibrosis
- T acute lymphoblastic leukemia
- precursor B-cell acute lymphoblastic leukemia
- primary myelofibrosis
role in cell
- apoptosis
- proliferation
- survival
- phosphorylation in
- expression in
- cellular infiltration by
- differentiation
- accumulation in
- adhesion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- intracellular membranes
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- cytoplasmic face of plasma membrane
- caveolar membranes
- membrane rafts
- paraspeckle-like structures
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Jak1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- interleukin-9-mediated signaling pathway
- tyrosine phosphorylation of STAT protein
- JAK-STAT cascade involved in growth hormone signaling pathway
- interleukin-4-mediated signaling pathway
- interferon-gamma-mediated signaling pathway
- positive regulation of homotypic cell-cell adhesion
- interleukin-11-mediated signaling pathway
- interleukin-2-mediated signaling pathway
- response to antibiotic
- protein phosphorylation
- JAK-STAT cascade
- type I interferon-mediated signaling pathway
- cytokine-mediated signaling pathway
- T-helper 17 cell lineage commitment
- interleukin-15-mediated signaling pathway
- cell differentiation
- interleukin-6-mediated signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- endosome
- focal adhesion
- cytoplasm
- extrinsic to internal side of plasma membrane
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- ubiquitin protein ligase binding
- protein phosphatase binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding
- growth hormone receptor binding
- CCR5 chemokine receptor binding