Pdilt Gene Summary [Rat]
Predicted to enable protein disulfide isomerase activity and protein folding chaperone. Predicted to be involved in protein folding. Predicted to act upstream of or within germ cell migration and spermatid development. Predicted to be active in endoplasmic reticulum. Orthologous to human PDILT (protein disulfide isomerase like, testis expressed). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdilt |
| Official Name | protein disulfide isomerase-like, testis expressed [Source:RGD Symbol;Acc:1307822] |
| Ensembl ID | ENSRNOG00000015368 |
| Bio databases IDs | |
| Aliases | protein disulfide isomerase-like, testis expressed |
| Synonyms | 1700007B13RIK, PDIA7, protein disulfide isomerase-like, testis expressed, RGD1307822 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdilt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- protein disulfide isomerase, eukaryotic
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- urolithiasis
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- renal failure
- kidney disease
- kidney stones
- hematuria
- urinary tract infection
- chronic kidney disease
- ureterolithiasis
regulated by
regulates
- Adam3
role in cell
- development
- function
- folding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdilt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- germ cell migration
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein disulfide isomerase activity
- protein binding involved in protein folding