Clgn Gene Summary [Rat]
Predicted to enable calcium ion binding activity and protein folding chaperone. Predicted to be involved in ERAD pathway and protein folding. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein-containing complex assembly. Predicted to be located in nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CLGN (calmegin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clgn |
| Official Name | calmegin [Source:RGD Symbol;Acc:1592643] |
| Ensembl ID | ENSRNOG00000003755 |
| Bio databases IDs | |
| Aliases | calmegin |
| Synonyms | 4930459O04Rik, A2/6, calmegin, Cln, LOC684301 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calreticulin family
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- macromolecular complex assembly
- protein folding
- single fertilization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- calcium ion binding
- unfolded protein binding