Zfp512b Gene Summary [Rat]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of miRNA transcription. Predicted to be located in nucleoplasm. Orthologous to human ZNF512B (zinc finger protein 512B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp512b |
| Official Name | zinc finger protein 512B [Source:RGD Symbol;Acc:1305284] |
| Ensembl ID | ENSRNOG00000015558 |
| Bio databases IDs | |
| Aliases | zinc finger protein 512B |
| Synonyms | GM632, Urkl1, Zfp512b, zinc finger protein 512B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp512b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
regulates
- mir-17 (includes others)
- MIR92A
- E2F1
- RAS
- mir-25 (includes others)
- MIR17HG
- DROSHA
- mir-19 (includes others)
role in cell
- expression in
- apoptosis
- proliferation
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp512b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription