Ebf3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Orthologous to human EBF3 (EBF transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ebf3 |
| Official Name | EBF transcription factor 3 [Source:RGD Symbol;Acc:1304956] |
| Ensembl ID | ENSRNOG00000016102 |
| Bio databases IDs | |
| Aliases | EBF transcription factor 3 |
| Synonyms | 3110018A08Rik, COE3, DKFZp667B0210, early B cell factor 3, EBF transcription factor 3, HADDS, mKIAA4201, O/E-2, OE-2, Olf-1/EBF-like 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ebf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- Transcription factor COE1 helix-loop-helix domain
- IPT
- double-stranded DNA binding
- IPT/TIG domain
- protein binding
- Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- hypotonia, ataxia and delayed development syndrome
- dementia
- hereditary disorder
- insomnia
- impotence
- restless legs syndrome
- mental retardation
- Mobius syndrome
- Pierre Robin syndrome
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- migration
- survival
- development
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ebf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity