Ccl1 Gene Summary [Rat]
Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in response to glucocorticoid. Predicted to be active in extracellular space. Biomarker of glomerulonephritis and nephrosis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple sclerosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human CCL1 (C-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl1 |
| Official Name | C-C motif chemokine ligand 1 [Source:RGD Symbol;Acc:1586495] |
| Ensembl ID | ENSRNOG00000021851 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 1 |
| Synonyms | C-C motif chemokine ligand 1, I-309, LOC688065, P500, SCYA1, SISe, TCA3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- juvenile rheumatoid arthritis
- eosinophilia
- rheumatoid arthritis
- bleomycin-induced pulmonary fibrosis
- age-related hearing loss
- early missed abortion
- pruritus
- multiorgan inflammation
- Rett syndrome
role in cell
- proliferation
- differentiation
- expression in
- apoptosis
- invasion
- migration
- ubiquitination in
- activation
- chemotaxis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of monocyte chemotaxis
- positive regulation of inflammatory response
- positive regulation of GTPase activity
- cellular calcium ion homeostasis
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- chemokine-mediated signaling pathway
- eosinophil chemotaxis
- positive regulation of interleukin-17 production
- viral reproduction
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CCR chemokine receptor binding
- chemokine activity