Dmrt3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmrt3 |
| Official Name | doublesex and mab-3 related transcription factor 3 [Source:RGD Symbol;Acc:1306043] |
| Ensembl ID | ENSRNOG00000016284 |
| Bio databases IDs | |
| Aliases | doublesex and mab-3 related transcription factor 3 |
| Synonyms | DMRTA3, doublesex and mab-3 related transcription factor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dmrt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- DM DNA binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- DMRTA motif
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphatic neoplasia
- lung adenocarcinoma formation
- epithelial cancer
- epithelial neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
regulated by
- PDLIM2
- cantharidin
- ESX1
regulates
role in cell
- abnormal morphology
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dmrt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adult walking behavior
- sex differentiation
- male sex differentiation
- regulation of odontogenesis of dentin-containing tooth
- transmission of nerve impulse
- ventral spinal cord interneuron specification
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity