Sat1 Gene Summary [Rat]
Enables N-acetyltransferase activity and spermidine binding activity. Involved in polyamine catabolic process and spermidine acetylation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in anxiety disorder and mood disorder. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sat1 |
| Official Name | spermidine/spermine N1-acetyl transferase 1 [Source:RGD Symbol;Acc:1586174] |
| Ensembl ID | ENSRNOG00000003809 |
| Bio databases IDs | |
| Aliases | spermidine/spermine N1-acetyl transferase 1 |
| Synonyms | Ab2-402, DC21, KFSD, KFSDX, SAT, Spermidine/spermine N1-acetyl transferase, spermidine/spermine N1-acetyl transferase 1, Spermidine supermine N1-acetyltransferase, SSAT, SSAT-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acetyltransferase (GNAT) family
- N-acetyltransferase
- NAT_SF
- acetyl CoA binding domain
- Acetyltransferase (GNAT) domain
- diamine N-acetyltransferase
- enzyme
- protein binding
- identical protein binding
- spermidine binding
- ribosomal-protein-alanine acetyltransferase
Pathways
Biological processes and signaling networks where the Sat1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pelvic cancer
- abdominal cancer
- urogenital cancer
- cancer
- endometriosis
- epithelial cancer
- epithelial neoplasia
- weight gain
- COVID-19
role in cell
- expression in
- growth
- apoptosis
- proliferation
- cell viability
- synthesis in
- depletion in
- cell death
- cytostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermidine acetylation
- angiogenesis
- polyamine biosynthetic process
- putrescine catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- spermidine binding
- diamine N-acetyltransferase activity
- N-acetyltransferase activity