Serpinb1a Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of macromolecule metabolic process; and type B pancreatic cell proliferation. Predicted to act upstream of or within regulation of protein catabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule and extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb1a |
| Official Name | serpin family B member 1A [Source:RGD Symbol;Acc:1306203] |
| Ensembl ID | ENSRNOG00000016581 |
| Bio databases IDs | |
| Aliases | serpin family B member 1A |
| Synonyms | 1190005M04Rik, EI, EIA, ELANH2, LEI, MNEI, M/NEI, Monocyte/neutrophil elastase inhibitor, PI2, serine (or cysteine) peptidase inhibitor, clade B, member 1a, Serpinb1, serpin family B member 1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinb1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- protease inhibitor
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neutropenia
- infection by bacteria
- experimental autoimmune encephalomyelitis
- sepsis
role in cell
- apoptosis
- chemotaxis
- frequency
- number
- function
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoplasmic ribonucleoprotein granule