Fancd2 Gene Summary [Rat]
Predicted to enable DNA polymerase binding activity. Predicted to be involved in several processes, including meiosis I; mitotic intra-S DNA damage checkpoint signaling; and response to gamma radiation. Predicted to act upstream of or within several processes, including neuronal stem cell population maintenance; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be part of DNA repair complex. Predicted to be active in condensed chromosome and nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group D2; and breast cancer. Orthologous to human FANCD2 (FA complementation group D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fancd2 |
| Official Name | FA complementation group D2 [Source:RGD Symbol;Acc:1303172] |
| Ensembl ID | ENSRNOG00000061085 |
| Bio databases IDs | |
| Aliases | FA complementation group D2 |
| Synonyms | 2410150O07RIK, AU015151, BB137857, FA4, FACD, FA complementation group D2, FAD, FA-D2, FANCD, Fanconi anaemia, complementation group D2, Fanconi anemia, complementation group D2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fancd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EDGE domain
- Fanconi anaemia protein FancD2 nuclease
- enzyme binding
- protein binding
- Fanconi anemia ID complex proteins FANCI and FANCD2
Pathways
Biological processes and signaling networks where the Fancd2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- non-squamous non-small cell lung cancer
- breast cancer
- lung cancer
- renal cancer
- endometrial cancer
- neoplasia
- ovarian cancer
role in cell
- differentiation
- synthesis in
- expression in
- proliferation
- binding in
- accumulation in
- cell death
- cell viability
- quantity
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- gamma H2AX nuclear focus
- Cytoplasm
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- synaptonemal complexes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fancd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of inflammatory response
- cellular response to oxidative stress
- regulation of regulatory T cell differentiation
- gamete generation
- brain morphogenesis
- intra-S DNA damage checkpoint
- regulation of CD40 signaling pathway
- response to gamma radiation
- synapsis
- neuronal stem cell maintenance
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- nuclear body
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA polymerase binding
- protein binding