Cela1 Gene Summary [Rat]
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | Cela1 |
| Official Name | chymotrypsin like elastase 1 [Source:RGD Symbol;Acc:2547] |
| Ensembl ID | ENSRNOG00000004725 |
| Bio databases IDs | |
| Aliases | chymotrypsin like elastase 1 |
| Synonyms | 1810009A17Rik, 1810062B19Rik, chymotrypsin like elastase 1, chymotrypsin-like elastase family, member 1, ELA1, ELAI1, PC-TsF, RATELAI1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cela1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- pancreatic elastase
Pathways
Biological processes and signaling networks where the Cela1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- soft tissue sarcoma cancer
- backache
- alveolar rhabdomyosarcoma
role in cell
- differentiation
- proliferation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cela1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- pancreas morphogenesis
- post-embryonic development
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of angiogenesis
- regulation of cell proliferation
- tissue remodeling
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- regulation of cell differentiation
- elastin catabolic process
- proteolysis
- Wnt receptor signaling pathway
- exocrine pancreas development
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- serine-type endopeptidase activity