Elane Gene Summary [Rat]
Predicted to enable several functions, including heparin binding activity; serine-type endopeptidase activity; and transcription corepressor activity. Involved in leukocyte migration involved in inflammatory response and positive regulation of leukocyte tethering or rolling. Predicted to be located in Golgi apparatus; cell surface; and secretory granule. Predicted to be part of transcription repressor complex. Predicted to be active in extracellular space. Used to study several diseases, including cerebrovascular disease (multiple); lung disease (multiple); mucositis; pleurisy; and polycythemia vera. Biomarker of suppurative periapical periodontitis. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (elastase, neutrophil expressed). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elane |
| Official Name | elastase, neutrophil expressed [Source:RGD Symbol;Acc:1307968] |
| Ensembl ID | ENSRNOG00000033685 |
| Bio databases IDs | |
| Aliases | elastase, neutrophil expressed |
| Synonyms | ELA2, ELASTASE, NEUTROPHIL, elastase, neutrophil expressed, F430011M15Rik, GE, Granulocyte Elastase, HLE, HNE, LEUKOCYTE ELASTASE, NE, Neutrophil elastase, PMN-E, SCN1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Elane often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- endopeptidase
- serine endopeptidase
- trypsin
- Tryp_SPc
- cytokine binding
- protease binding
- leukocyte elastase
- transcription co-repressor
- peptidase
- protein binding
- heparin binding
Pathways
Biological processes and signaling networks where the Elane gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute graft-vs-host disease
- COVID-19
- inflammatory disorder
- autosomal dominant severe congenital neutropenia type 1
- alpha-1-antitrypsin deficiency
- autoinflammatory disorder
- colorectal cancer
- chronic obstructive pulmonary disease
- metaplasia
role in cell
- growth
- expression in
- binding
- apoptosis
- adhesion
- cell death
- proliferation
- formation
- migration
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular trap
- intracellular membrane-bounded organelle
- secretory granule lumen
- azurophil granule lumen
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- granules
- cytosol
- nucleoplasm
- nuclear envelope
- azurophil granules
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Elane gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- neutrophil mediated killing of fungus
- response to UV
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of smooth muscle cell proliferation
- acute inflammatory response to antigenic stimulus
- biosynthetic process of antibacterial peptides active against Gram-negative bacteria
- pyroptosis
- neutrophil mediated killing of gram-negative bacterium
- positive regulation of immune response
- negative regulation of chemokine production
- protein catabolic process
- negative regulation of inflammatory response
- extracellular matrix disassembly
- defense response to bacterium
- cellular calcium ion homeostasis
- positive regulation of interleukin-8 production
- leukocyte migration involved in inflammatory response
- response to yeast
- negative regulation of interleukin-8 production
- proteolysis
- phagocytosis
- response to lipopolysaccharide
- negative regulation of chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- specific granule lumen
- transcriptional repressor complex
- secretory granule
- phagocytic vesicle
- cytosol
- extracellular region
- azurophil granule lumen
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- endopeptidase activity
- serine-type endopeptidase activity
- heparin binding
- protease binding
- peptidase activity
- cytokine binding