Hoxc4 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glial cell derived neurotrophic factor and positive regulation of male germ-line stem cell asymmetric division. Predicted to be located in nucleoplasm. Orthologous to human HOXC4 (homeobox C4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxc4 |
| Official Name | homeo box C4 [Source:RGD Symbol;Acc:1586210] |
| Ensembl ID | ENSRNOG00000016613 |
| Bio databases IDs | |
| Aliases | homeo box C4 |
| Synonyms | homeo box C4, Hox3r3 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein domain specific binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Hoxc4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm