Spire2 Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Orthologous to human SPIRE2 (spire type actin nucleation factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spire2 |
| Official Name | spire-type actin nucleation factor 2 [Source:RGD Symbol;Acc:1305837] |
| Ensembl ID | ENSRNOG00000016920 |
| Bio databases IDs | |
| Aliases | spire-type actin nucleation factor 2 |
| Synonyms | Spir-2, spire-type actin nucleation factor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spire2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- Protein Kinases, catalytic domain
- WH2
- protein binding
- Kinase non-catalytic C-lobe domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colon cancer
- age-related hearing loss
- neuroblastoma
- neuroblastoma formation
- epithelial basal cell carcinoma
- osteoarthritis
regulated by
- D-alpha-hydroxyglutarate
- SLC7A5
- Zn2+
- oocytes
- Caco2 cells
role in cell
- formation
- organization
- formation in
- localization
- cytokinesis in
- positioning in
- positioning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cell cortex
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spire2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polar body extrusion after meiotic divisions
- cleavage furrow formation
- formin-nucleated actin cable assembly
- intracellular transport
- protein transport
- actin filament polymerization
- vesicle-mediated transport
- actin nucleation
- establishment of meiotic spindle localization
- actin filament network formation
- positive regulation of double-strand break repair
- actin cytoskeleton organization
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- cytoskeleton
- cleavage furrow
- cell cortex
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin binding
- microtubule binding