Slc7a5 Gene Summary [Rat]
Enables amino acid transmembrane transporter activity. Involved in several processes, including branched-chain amino acid transport; cellular response to L-arginine; and liver regeneration. Located in basolateral plasma membrane and external side of apical plasma membrane. Used to study high grade glioma. Biomarker of hepatocellular carcinoma and transitional cell carcinoma. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc7a5 |
| Official Name | solute carrier family 7 member 5 [Source:RGD Symbol;Acc:620639] |
| Ensembl ID | ENSRNOG00000018824 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 5 |
| Synonyms | 4F2LC, CD98, CD98LC, CD98 LIGHT CHAIN, D0H16S474E, D16S469E, E16, Gm42049, Large neutral amino acid transporter 1, LAT-1, MPE16, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5, solute carrier family 7 member 5, TA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc7a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine transporter
- L-amino acid transporter
- protein binding
- aromatic amino acid transporter
- neutral amino acid transporter
- tryptophan transporter
- amino acid permease
- antiporter
- L-type amino acid transporter
- thyroid hormone transporter
- peptide antigen binding
- amino acid transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc7a5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- obesity
- breast cancer
- colorectal cancer
- small cell lung cancer
- non-small cell lung cancer
- colon cancer
- uterine serous papillary cancer
- androgenic alopecia
role in cell
- expression in
- activation in
- proliferation
- phosphorylation in
- differentiation
- quantity
- binding
- growth
- production in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
- basal membrane
- microsomal membrane
- membrane rafts
- microvilli
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc7a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- amino acid transmembrane transport
- alanine transport
- valine transport
- positive regulation of interferon-gamma production
- tyrosine transport
- tryptophan transport
- positive regulation of interleukin-17 production
- neutral amino acid transport
- proline transport
- phenylalanine transport
- methionine transport
- thyroid hormone transport
- leucine transport
- response to muscle activity
- positive regulation of glial cell proliferation
- cellular response to glucose starvation
- positive regulation of cytokine production involved in immune response
- negative regulation of gene expression
- cellular response to lipopolysaccharide
- isoleucine transport
- negative regulation of autophagy
- xenobiotic transport
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- basal plasma membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- L-amino acid transmembrane transporter activity
- protein binding
- peptide antigen binding
- antiporter activity
- neutral amino acid transmembrane transporter activity
- L-tryptophan transmembrane transporter activity
- aromatic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- thyroid hormone transmembrane transporter activity
- L-leucine transmembrane transporter activity