Fez1 Gene Summary [Rat]
Enables protein kinase C binding activity. Involved in several processes, including hippocampus development; positive regulation of anterograde axonal transport of mitochondrion; and positive regulation of neuron projection development. Located in dendrite; growth cone; and neuronal cell body. Biomarker of Parkinson's disease. Orthologous to human FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fez1 |
| Official Name | fasciculation and elongation protein zeta 1 [Source:RGD Symbol;Acc:619708] |
| Ensembl ID | ENSRNOG00000006075 |
| Bio databases IDs | |
| Aliases | fasciculation and elongation protein zeta 1 |
| Synonyms | fasciculation and elongation protein zeta 1, fasciculation and elongation protein ζ 1, UNC-76 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fez1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- protein kinase C binding
- FEZ-like protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- invasive breast carcinoma
- breast carcinoma
- invasive breast cancer
- schizophrenia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- peripheral arterial disease
- endometrial adenocarcinoma
regulates
- FEZ1
- Agnoprotein
- Vp1
- dopamine
role in cell
- outgrowth
- adhesion
- differentiation
- development
- guidance
- assembly
- organization
- fasciculation
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- Plasma Membrane
- centrosome
- Golgi Apparatus
- growth cone
- cellular protrusions
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fez1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of mitochondrion localization
- cellular response to growth factor stimulus
- nervous system development
- axon guidance
- establishment of cell polarity
- hippocampus development
- cell adhesion
- positive regulation of neuron projection development
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- growth cone
- dendrite
- centrosome
- cytoplasm
- Golgi apparatus
- neuronal cell body
- axon
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding
- gamma-tubulin binding