Adam18 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in cell differentiation; proteolysis; and spermatogenesis. Predicted to be located in membrane. Orthologous to human ADAM18 (ADAM metallopeptidase domain 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam18 |
| Official Name | ADAM metallopeptidase domain 18 [Source:RGD Symbol;Acc:620405] |
| Ensembl ID | ENSRNOG00000017683 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 18 |
| Synonyms | ADAM27, ADAM metallopeptidase domain 18, a disintegrin and metallopeptidase domain 18, Dtgn3, Tmdc3, tMDCIII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- metallopeptidase
- EB module
- ZnMc
- ADAM cysteine-rich
- peptidase
- integrin binding
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- Tenascin EGF domain
Pathways
Biological processes and signaling networks where the Adam18 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- male gonad development
- spermatogenesis
- proteolysis
- cell differentiation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metalloendopeptidase activity
- metallopeptidase activity