Dynlt1 Gene Summary [Rat]
Enables transmembrane transporter binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; neuron projection development; and positive regulation of Rac protein signal transduction. Located in axonal growth cone; lamellipodium; and neuronal cell body. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dynlt1 |
| Official Name | dynein light chain Tctex-type 1 [Source:RGD Symbol;Acc:620261] |
| Ensembl ID | ENSRNOG00000018207 |
| Bio databases IDs | |
| Aliases | dynein light chain Tctex-type 1 |
| Synonyms | AGS2, CW-1, dynein light chain Tctex-type 1, TCTEL1, TCTEX1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dynlt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tctex-1 family
- GTP-dependent protein binding
- dynein light chain (DLC)-like domain superfamily
- ion channel binding
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Dynlt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- HER2-positive breast cancer
- luminal A breast cancer
- HER2 negative hormone receptor negative breast cancer
- luminal B breast cancer
role in cell
- apoptosis
- expression in
- migration
- proliferation
- degradation in
- organization
- transmembrane potential
- specification
- binding in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axon component
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- perinuclear region
- Nucleus
- vesicles
- Golgi Apparatus
- Mitochondria
- microtubules
- nuclear envelope
- synaptic vesicles
- growth cone
- photoreceptor inner segments
- secretory vesicles
- multivesicular bodies
- smooth endoplasmatic reticulum
- cytoplasmic microtubule
- perikaryon
- axons
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dynlt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cell division
- establishment of mitotic spindle orientation
- intracellular transport of viral proteins in host cell
- nervous system development
- negative regulation of neurogenesis
- regulation of G-protein coupled receptor protein signaling pathway
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- cytoplasmic dynein complex
- cytoplasm
- dynein complex
- spindle
- secretory granule lumen
- Golgi apparatus
- cytoplasmic microtubule
- extracellular region
- host cell
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein intermediate chain binding