Bmpr2 Gene Summary [Rat]
Enables growth factor binding activity. Involved in retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmpr2 |
| Official Name | bone morphogenetic protein receptor type 2 [Source:RGD Symbol;Acc:71082] |
| Ensembl ID | ENSRNOG00000022196 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein receptor type 2 |
| Synonyms | 2610024H22RIK, BB189135, BMP-2, BMPR3, BMPR-II, BMR2, bone morphogenetic protein receptor type 2, BRK-3, Gm20272, POVD1, PPH1, T-ALK, Type ii bmp receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmpr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- Activin types I and II receptor domain
- cytokine binding
- Protein kinase domain
- transmembrane receptor protein serine/threonine kinase
- cytoplasmic domain
- cadherin binding
- tail domain
- TFP
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- ectodomain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- type II activin receptor
- Protein Kinases, catalytic domain
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Bmpr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- Epithelial Adherens Junction Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
- Osteoarthritis Pathway
- PPARα/RXRα Activation
- PTEN Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
- STAT3 Pathway
- TGF-β Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- cancer
- hyperplasia
- metastasis
- primary pulmonary hypertension 1
- pulmonary venoocclusive disease type 1
- primary pulmonary hypertension
- pulmonary hypertensive arterial disease
- pancreatic cancer
- vascular leak syndrome
role in cell
- production in
- expression in
- function
- quantity
- calcification
- apoptosis
- growth
- binding in
- interaction in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- apical membrane
- caveolae
- basal membrane
- nucleoplasm
- neuromuscular junctions
- clathrin-coated pits
- perikaryon
- axons
- dendrites
- postsynaptic density
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmpr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina vasculature development in camera-type eye
- anterior/posterior pattern specification
- negative regulation of cell proliferation involved in heart valve morphogenesis
- transmembrane receptor protein serine/threonine kinase signaling pathway
- aortic valve development
- pulmonary valve development
- artery development
- venous blood vessel development
- activin receptor signaling pathway
- lung alveolus development
- cellular response to BMP stimulus
- negative regulation of cell growth
- BMP signaling pathway
- lymphangiogenesis
- mesoderm formation
- positive regulation of bone mineralization
- atrioventricular valve morphogenesis
- endochondral bone morphogenesis
- mitral valve morphogenesis
- tricuspid valve morphogenesis
- lymphatic endothelial cell differentiation
- positive regulation of axon extension involved in axon guidance
- positive regulation of ossification
- positive regulation of gene expression
- cellular response to growth factor stimulus
- endothelial cell apoptotic process
- positive regulation of cartilage development
- negative regulation of vasoconstriction
- outflow tract morphogenesis
- lung vasculature development
- chondrocyte development
- endocardial cushion development
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- cardiac muscle tissue development
- maternal placenta development
- outflow tract septum morphogenesis
- negative regulation of muscle cell differentiation
- blood vessel development
- regulation of lung blood pressure
- negative regulation of smooth muscle cell proliferation
- osteoblast differentiation
- positive regulation of SMAD protein import into nucleus
- proteoglycan biosynthetic process
- positive regulation of epithelial cell migration
- limb development
- negative regulation of systemic arterial blood pressure
- cellular response to starvation
- ventricular septum morphogenesis
- atrial septum morphogenesis
- regulation of cell proliferation
- blood vessel remodeling
- endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- receptor complex
- neuronal cell body
- plasma membrane
- cell surface
- nucleoplasm
- dendrite
- caveola
- basal plasma membrane
- adherens junction
- extracellular space
- coated pit
- apical plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- BMP binding
- ATP binding
- growth factor binding
- protein binding
- metal ion binding
- cadherin binding
- activin receptor activity, type II
- transforming growth factor beta-activated receptor activity