Dnaja2 Gene Summary [Rat]
Predicted to enable ATPase activator activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Involved in carbon tetrachloride metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Biomarker of liver disease. Orthologous to human DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaja2 |
| Official Name | DnaJ heat shock protein family (Hsp40) member A2 [Source:RGD Symbol;Acc:71001] |
| Ensembl ID | ENSRNOG00000016251 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member A2 |
| Synonyms | 1500017M13RIK, 2010206B19RIK, CPR3, DJ3, DJA2, DNAJ, Dnaj3, DnaJ heat shock protein family (Hsp40) member A2, DNJ3, DNJA2, HIRIP4, mDj3, PRO3015, RDJ2, Similar to hsp40 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnaja2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- chaperone protein DnaJ
- DnaJ central domain
- enzyme
- protein binding
- prenylation site
- hsp70 binding domain
- DnaJ domain
- Zinc finger domain of DnaJ and HSP40
- DnaJ
- DnaJ molecular chaperone homology domain
- DnaJ C terminal domain
- chaperone binding
- farnesylation site
Pathways
Biological processes and signaling networks where the Dnaja2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- productive infection by HIV-1
role in cell
- phosphorylation in
- formation in
- proliferation
- expression in
- production in
- formation
- differentiation
- binding in
- generation
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnaja2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to heat
- positive regulation of cell proliferation
- protein refolding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- chaperone binding
- unfolded protein binding
- ATPase activator activity
- Hsp70 protein binding