Vdac1 Gene Summary [Rat]
Enables voltage-gated monoatomic anion channel activity. Involved in calcium import into the mitochondrion. Located in mitochondrial outer membrane and synaptic vesicle. Part of protein-containing complex. Is active in postsynaptic density membrane and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human VDAC1 (voltage dependent anion channel 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vdac1 |
| Official Name | voltage-dependent anion channel 1 [Source:RGD Symbol;Acc:621575] |
| Ensembl ID | ENSRNOG00000006375 |
| Bio databases IDs | |
| Aliases | voltage-dependent anion channel 1 |
| Synonyms | Brain Derived Voltage-Dependent Ion Channel, LOC105379185, mVDAC1, mVDAC5, Nadh fecn reductase, PORIN, PORIN 31HM, VDAC, Vdac5, VOLTAGE DEPENDENT ANION CHANNEL, voltage-dependent anion channel 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vdac1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- oxysterol binding
- sphingolipid binding
- cholesterol binding
- protein kinase binding
- calcium channel
- Eukaryotic porin family that forms channels in the mitochondrial outer membrane
- channel/pore class transporter
- protein binding
- identical protein binding
- ion channel
- anion channel
- Eukaryotic porin
- binding protein
- voltage-dependent ion-selective channel
- ion channel binding
- voltage-gated ion channel
Pathways
Biological processes and signaling networks where the Vdac1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- sickle cell anemia
- epithelial cancer
- lung adenocarcinoma formation
- organismal death
- adenomyosis
- hepatocellular carcinoma
- liver cancer
- lung cancer
- Alzheimer disease
role in cell
- cell viability
- expression in
- apoptosis
- cell death
- migration
- production in
- proliferation
- activation in
- binding in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- mitochondrial envelope
- cell surface
- outer membranes
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- myofilaments
- microsome
- presynaptic membrane
- synaptic membrane
- Golgi membrane
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
- nuclear envelope
- nuclear scaffolds
- synaptic vesicles
- neurites
- mitoplasts
- microsomal membrane
- membrane rafts
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vdac1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- neuron-neuron synaptic transmission
- negative regulation of apoptotic process
- apoptotic process
- anion transport
- learning
- pyruvate metabolic process
- behavioral fear response
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- pore complex
- synapse
- mitochondrial outer membrane
- plasma membrane
- mitochondrial nucleoid
- nucleus
- extracellular vesicular exosome
- mitochondrial membrane
- mitochondrial permeability transition pore complex
- membrane raft
- mitochondrion
- membrane
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- protein kinase binding
- identical protein binding
- voltage-gated anion channel activity
- protein binding
- porin activity
- cholesterol binding
- oxysterol binding
- phosphatidylcholine binding
- ion channel binding