Slc22a6 Gene Summary [Rat]
Enables several functions, including chloride ion binding activity; prostaglandin transmembrane transporter activity; and secondary active transmembrane transporter activity. Involved in metanephric proximal tubule development; prostaglandin transport; and sodium-independent organic anion transport. Acts upstream of or within organic anion transport. Located in caveola. Part of protein-containing complex. Orthologous to human SLC22A6 (solute carrier family 22 member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc22a6 |
| Official Name | solute carrier family 22 member 6 [Source:RGD Symbol;Acc:69338] |
| Ensembl ID | ENSRNOG00000018215 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 member 6 |
| Synonyms | HOAT1, mOat1, NKT, OAT1, Orctl1, PAHT, ROAT1, solute carrier family 22 member 6, solute carrier family 22 (organic anion transporter), member 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc22a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- benzoate transport
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- phosphate:H+ symporter
- protein binding
- alpha-ketoglutarate transporter
- organic anion transporter
- identical protein binding
- prostaglandin transporter
- phosphoglycerate transporter family protein
- binding protein
- Sugar (and other) transporter
- xenobiotic transporter
- antiporter
- inorganic anion exchanger
- cation transport protein
- transporter
Pathways
Biological processes and signaling networks where the Slc22a6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- gout
- non-tophaceous gout
- urinary tract infection
- headache
- complicated urinary tract infection
- insomnia
- diabetic nephropathy
- intra-abdominal infection
- proximal tubular toxicity
regulated by
- deoxycholate
- rifampin
- acetazolamide
- cimetidine
- indomethacin
- ibuprofen
- rhein
- hydrocortisone
- lycopene
- LHX1
regulates
- 2-oxoglutaric acid
- organic anion
- salicylic acid
- p-aminohippuric acid
- 4-hydroxyphenylpyruvic acid
- radical
- 6-carboxyfluorescein
- cidofovir
- prostaglandin
- alpha-keto-beta-methylvaleric acid
role in cell
- cell death
- production in
- proliferation
- cell viability
- replication in
- uptake in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- caveolae
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc22a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inorganic anion transport
- alpha-ketoglutarate transport
- renal tubular secretion
- transmembrane transport
- sodium-independent organic anion transport
- xenobiotic transport
- metanephric proximal tubule development
- response to organic cyclic compound
- anion transport
- organic anion transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- caveola
- basal plasma membrane
- extracellular vesicular exosome
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- identical protein binding
- chloride ion binding
- protein binding
- transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- antiporter activity
- inorganic anion exchanger activity
- organic anion transmembrane transporter activity
- alpha-ketoglutarate transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity