SLC22A6 Gene Summary [Human]

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Nonsense Mediated Decay
Official Symbol
SLC22A6
Official Name
solute carrier family 22 member 6 [Source:HGNC Symbol;Acc:HGNC:10970]
Ensembl ID
ENSG00000197901
Bio databases IDs NCBI: 9356 Ensembl: ENSG00000197901
Aliases solute carrier family 22 member 6
Synonyms HOAT1, mOat1, NKT, OAT1, Orctl1, PAHT, ROAT1, solute carrier family 22 member 6, solute carrier family 22 (organic anion transporter), member 6
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC22A6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • benzoate transport
  • Major Facilitator Superfamily
  • sodium-independent organic anion transporter
  • phosphate:H+ symporter
  • protein binding
  • alpha-ketoglutarate transporter
  • organic anion transporter
  • identical protein binding
  • prostaglandin transporter
  • phosphoglycerate transporter family protein
  • binding protein
  • Sugar (and other) transporter
  • xenobiotic transporter
  • antiporter
  • inorganic anion exchanger
  • cation transport protein
  • transporter

Pathways

Biological processes and signaling networks where the SLC22A6 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • FGFR2
  • CHPT1
  • p-aminohippuric acid
  • HNF4A
  • probenecid
  • lesinurad
  • omega-hydroxypalmitic acid
  • SFXN5
  • palmitoleic acid
  • benzoic acid
disease
  • HIV infection
  • gout
  • non-tophaceous gout
  • urinary tract infection
  • headache
  • complicated urinary tract infection
  • insomnia
  • diabetic nephropathy
  • intra-abdominal infection
  • proximal tubular toxicity
regulated by
  • deoxycholate
  • rifampin
  • acetazolamide
  • cimetidine
  • indomethacin
  • ibuprofen
  • rhein
  • hydrocortisone
  • lycopene
  • LHX1
regulates
  • 2-oxoglutaric acid
  • organic anion
  • salicylic acid
  • p-aminohippuric acid
  • 4-hydroxyphenylpyruvic acid
  • radical
  • 6-carboxyfluorescein
  • cidofovir
  • prostaglandin
  • alpha-keto-beta-methylvaleric acid
role in cell
  • cell death
  • production in
  • proliferation
  • cell viability
  • replication in
  • uptake in
  • transport in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • caveolae
  • basolateral membrane
  • basal membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC22A6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • inorganic anion transport
  • alpha-ketoglutarate transport
  • renal tubular secretion
  • transmembrane transport
  • sodium-independent organic anion transport
  • xenobiotic transport
  • metanephric proximal tubule development
  • response to organic cyclic compound
  • anion transport
  • organic anion transport
  • prostaglandin transport

Cellular Component

Where in the cell the gene product is active
  • caveola
  • basal plasma membrane
  • extracellular vesicular exosome
  • macromolecular complex
  • basolateral plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • xenobiotic transporter activity
  • identical protein binding
  • chloride ion binding
  • protein binding
  • transmembrane transporter activity
  • prostaglandin transmembrane transporter activity
  • antiporter activity
  • inorganic anion exchanger activity
  • organic anion transmembrane transporter activity
  • alpha-ketoglutarate transmembrane transporter activity
  • sodium-independent organic anion transmembrane transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.