Dhrs4 Gene Summary [Rat]
Predicted to enable several functions, including 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; alcohol dehydrogenase (NADP+) activity; and retinal dehydrogenase activity. Predicted to be involved in several processes, including positive regulation of reactive oxygen species metabolic process; retinal metabolic process; and steroid metabolic process. Located in peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhrs4 |
| Official Name | dehydrogenase/reductase 4 [Source:RGD Symbol;Acc:708482] |
| Ensembl ID | ENSRNOG00000018239 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase 4 |
| Synonyms | CR, Dehydrogenase/Reductase, dehydrogenase/reductase 4, LOC266686, NRDR, PEROXISOMAL short CHAIN ALCOHOL DEHYDROGENASE, PHCR, PSCD, SCAD-SRL, SDR25C1, SDR25C2, SDR-SRL |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhrs4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- 3-keto sterol reductase
- retinal dehydrogenase
- KR domain
- pteridine reductase
- enzyme
- Enoyl-(Acyl carrier protein) reductase
- 3-oxoacyl-(acyl-carrier-protein) reductase, putative
- identical protein binding
- alcohol dehydrogenase [NAD(P)]
- carbonyl reductase (NADPH)
- polyketide synthase keto reductase domain
- sepiapterin reductase
- acetoin reductases
- short chain dehydrogenase
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Dhrs4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Nucleus
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhrs4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular ketone metabolic process
- retinol metabolic process
- steroid metabolic process
- alcohol metabolic process
- retinal metabolic process
- positive regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum membrane
- peroxisome
- nucleus
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- carbonyl reductase (NADPH) activity
- 3-keto sterol reductase activity
- identical protein binding
- 3beta-hydroxy-5beta-steroid dehydrogenase activity
- NADP-retinol dehydrogenase activity
- retinal dehydrogenase activity
- alcohol dehydrogenase [NAD(P)+] activity
- oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor