Eps8l2 Gene Summary [Rat]
Predicted to enable actin binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in centrosome; cytosol; and stereocilium tip. Predicted to be part of protein-containing complex. Predicted to be active in ruffle membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 106. Orthologous to human EPS8L2 (EPS8 signaling adaptor L2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eps8l2 |
| Official Name | EPS8-like 2 [Source:RGD Symbol;Acc:1310912] |
| Ensembl ID | ENSRNOG00000018336 |
| Bio databases IDs | |
| Aliases | EPS8-like 2 |
| Synonyms | DFNB106, EPS8-like 2, EPS8R2, EPS8 signaling adaptor L2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eps8l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- SAM (Sterile alpha motif )
- actin binding
- guanyl-nucleotide exchange factor
- SAM domain (Sterile alpha motif)
- protein binding
- Pleckstrin homology-like domain
- zDHHC ankyrin repeat binding domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 106
- age-related hearing loss
- familial nonsyndromic hearing impairment
regulates
role in cell
- morphology
- abnormal morphology
- number
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- stereocilia tip
- ruffle
- centrosome
- cytosol
- stereocilia
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eps8l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of Rho protein signal transduction
- Rho protein signal transduction
- positive regulation of ruffle assembly
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- stereocilium bundle
- vesicle
- cytosol
- ruffle membrane
- macromolecular complex
- stereocilium bundle tip
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- guanyl-nucleotide exchange factor activity