Dnajb6 Gene Summary [Rat]
Predicted to enable several functions, including ATPase activator activity; identical protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone-mediated protein folding; intermediate filament organization; and negative regulation of inclusion body assembly. Predicted to act upstream of or within several processes, including chorion development; labyrinthine layer development; and negative regulation of DNA-templated transcription. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1. Orthologous to human DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajb6 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B6 [Source:RGD Symbol;Acc:1308207] |
| Ensembl ID | ENSRNOG00000010353 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B6 |
| Synonyms | DJ4, DnaJ, DnaJ heat shock protein family (Hsp40) member B6, Heat shock protein J2, HHDJ1, HSJ-2, LGMD1D, LGMD1E, LGMDD1, LOC108350642, mDj4, MRJ, MSJ-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnajb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- ATPase stimulator
- DnaJ
- transcription regulator
- DnaJ molecular chaperone homology domain
- heat shock protein binding
- nuclear localization sequence
- protein binding
- chaperone binding
- identical protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Dnajb6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- limb-girdle muscular dystrophy type 1E
- Parkinson disease
- dry eye syndrome
- glioblastoma
- glioblastoma cancer
- Rett syndrome
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- late-onset Parkinson disease
role in cell
- phosphorylation in
- expression in
- proliferation
- cell death
- survival
- cell viability
- formation
- aggregation in
- assembly
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- Z line
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnajb6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- regulation of cellular response to heat
- chaperone-mediated protein folding
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development
- protein folding
- negative regulation of inclusion body assembly
- intermediate filament organization
- chorio-allantoic fusion
- negative regulation of transcription, DNA-dependent
- chorion development
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- extracellular matrix organization
- actin cytoskeleton organization
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- heat shock protein binding
- protein binding involved in protein folding
- protein binding
- chaperone binding
- unfolded protein binding
- ATPase activator activity
- Hsp70 protein binding