Sos1 Gene Summary [Rat]
Enables SH3 domain binding activity and epidermal growth factor receptor binding activity. Involved in several processes, including Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Located in neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Used to study brain ischemia. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; atrial heart septal defect; gingival fibromatosis; and pulmonary valve stenosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sos1 |
| Official Name | SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:RGD Symbol;Acc:1310949] |
| Ensembl ID | ENSRNOG00000007106 |
| Bio databases IDs | |
| Aliases | SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Synonyms | 4430401P03RIK, 9630010N06, AI449023, GF1, GGF1, GINGF, HGF, MSOS1, NS4, Sos, SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sos1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- Ras exchanger motif
- protein kinase binding
- catalytic domain
- epidermal growth factor receptor binding
- protein binding activity, bridging
- GTPase activator
- protein binding
- RasGEF
- Pleckstrin homology-like domain
- Cdc25 domain
- proline rich domain
- RhoGEF domain
- SH3-domain binding
- Grb2 binding domain
- Sh3 domain binding motif
- histone fold domain (HFD) superfamily
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- Dbl homology domain
- guanine nucleotide exchange factor domain
- REM
Pathways
Biological processes and signaling networks where the Sos1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- CNTF Signaling
- EGF Signaling
- ErbB Signaling
- ErbB2-ErbB3 Signaling
- ErbB4 Signaling
- FGF Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- IL-2 Signaling
- IL-7 Signaling Pathway
- Integrin Signaling
- JAK/Stat Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PAK Signaling
- Paxillin Signaling
- PPAR Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Renal Cell Carcinoma Signaling
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- tumorigenesis
- Noonan syndrome
- gingival fibromatosis type 1
- hereditary disorder
- Noonan Syndrome type 4
- Noonan spectrum disorder
- Noonan syndrome type 1
- lung adenocarcinoma
role in cell
- expression in
- growth
- adhesion
- activation in
- proliferation
- morphology
- phosphorylation in
- migration
- cell viability
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- glutaminergic synapse
- podosome rosette
- cellular membrane
- podosomes
- Plasma Membrane
- cytosol
- perikaryon
- postsynaptic density
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sos1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- Schwann cell development
- vitellogenesis
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- palate development
- Fc-epsilon receptor signaling pathway
- positive regulation of epidermal growth factor receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- axon guidance
- blood vessel morphogenesis
- myelination
- regulation of T cell differentiation in thymus
- response to ischemia
- hair follicle development
- cytokine-mediated signaling pathway
- cardiac atrium morphogenesis
- regulation of pro-B cell differentiation
- B cell receptor signaling pathway
- regulation of T cell proliferation
- signal transduction
- heart trabecula morphogenesis
- insulin-like growth factor receptor signaling pathway
- Ras protein signal transduction
- regulation of cell proliferation
- pericardium morphogenesis
- B cell homeostasis
- eyelid development in camera-type eye
- regulation of transcription from RNA polymerase II promoter
- nerve growth factor receptor signaling pathway
- positive regulation of small GTPase mediated signal transduction
- leukocyte migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- guanyl-nucleotide exchange factor activity
- GTPase activator activity
- epidermal growth factor receptor binding
- SH3 domain binding