Lrrc4b Gene Summary [Rat]
Predicted to enable signaling receptor binding activity. Involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human LRRC4B (leucine rich repeat containing 4B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc4b |
| Official Name | leucine rich repeat containing 4B [Source:RGD Symbol;Acc:1307121] |
| Ensembl ID | ENSRNOG00000019418 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 4B |
| Synonyms | A830007M12, HSM, leucine rich repeat containing 4B, LRC4B, LRIG4, NGL-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrrc4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- extracellular domain
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- receptor binding
- Leucine Rich repeats (2 copies)
- cytoplasmic domain
- Immunoglobulin like
- Leucine rich repeat N-terminal domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cervical cancer
- schizophrenia
- epithelial uterine cancer
- metastasis
- colorectal cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
role in cell
- adhesion
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- synaptic membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrrc4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cerebellar mossy fiber
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- receptor binding