Gria2 Gene Summary [Rat]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Gria2 |
| Official Name | glutamate ionotropic receptor AMPA type subunit 2 [Source:RGD Symbol;Acc:61862] |
| Ensembl ID | ENSRNOG00000054204 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor AMPA type subunit 2 |
| Synonyms | GluA2, GLUR2, GLURB, GluR-K2, glutamate ionotropic receptor AMPA type subunit 2, glutamate receptor, ionotropic, AMPA2 (alpha 2), glutamate receptor, ionotropic, AMPA2 (α 2), HBGR2, NEDLIB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gria2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- ligand binding sub-domain D1
- PKC phosphorylation site
- identical protein binding
- ion channel
- kainate selective glutamate receptor
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor
- cytoskeletal protein binding
- S1 domain
- ligand-binding domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- tail domain
- membrane-proximal domain
- extracellular domain
- Receptor family ligand binding region
- protein kinase binding
- signaling receptor activity
- channel/pore class transporter
- calcium channel
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- glutamate-gated ion channel
- beta-amyloid binding
- extracellular ligand-gated ion channel
- protein binding
- receptor binding
- ionotropic glutamate receptor binding
- immunoglobulin binding
- PDZ-domain binding
- ligand binding sub-domain D2
- binding protein
- neurotransmitter receptor
- NSF binding domain
- ligand-gated ion channel
- cytosolic tail domain
- PDZ binding motif
- cation channel
Pathways
Biological processes and signaling networks where the Gria2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- neurodevelopmental disorder with language impairment and behavioral abnormalities
- neurodegeneration
- Alzheimer disease
- atopic dermatitis
- diabetic nephropathy
- bipolar disorder
- seizures
- peripheral arterial disease
- uterine leiomyoma
role in cell
- cell death
- apoptosis
- binding in
- expression in
- migration
- depolarization
- degeneration
- long-term potentiation
- long term synaptic depression
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- detergent-soluble membrane fractions
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- subsynaptic membrane
- endocytic vesicle membrane
- Cytoplasm
- presynaptic regions
- cell surface
- Extracellular Space
- intracellular space
- somatodendritic region
- perinuclear region
- postsynaptic region
- membrane surface
- cellular membrane
- Endoplasmic Reticulum
- membrane compartment
- granules
- microsome
- plasma membrane extracellular face
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- dendritic spine neck
- dendritic spine head
- synaptic vesicles
- growth cone
- neurites
- dendrite initial segments
- synaptosomes
- synapse
- cellular protrusions
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
- dendritic branches
- detergent-soluble fraction
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gria2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- signal transduction
- synaptic transmission
- regulation of synaptic transmission
- ionotropic glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- postsynaptic density
- dendrite
- excitatory synapse
- dendritic spine
- external side of plasma membrane
- asymmetric synapse
- neuronal cell body
- plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- ionotropic glutamate receptor activity
- beta-amyloid binding