Slc5a2 Gene Summary [Rat]
Enables D-glucose:sodium symporter activity. Involved in D-glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in familial renal glucosuria and renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc5a2 |
| Official Name | solute carrier family 5 member 2 [Source:RGD Symbol;Acc:620217] |
| Ensembl ID | ENSRNOG00000020039 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 member 2 |
| Synonyms | GLYS1, SGLT2, solute carrier family 5 member 2, solute carrier family 5 (sodium/glucose cotransporter), member 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc5a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- glucose:sodium symporter
- alpha-glucoside transporter
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- low-affinity glucose:sodium symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- congestive heart failure
- systolic heart failure
- acute decompensated heart failure
- kidney disease
- vascular disease
- cardiovascular disorder
- nephrosis
- heart failure
- non-insulin-dependent diabetes mellitus
regulates
- GCG
- carbohydrate
- D-glucose
- hexose
- D-galactose
- mannose
- D-fructose
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc5a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- sodium ion transport
- alpha-glucoside transport
- hexose transport
- renal glucose absorption
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- D-glucose transmembrane transporter activity
- alpha-glucoside transmembrane transporter activity
- low-affinity glucose:sodium symporter activity
- glucose:sodium symporter activity