Anln Gene Summary [Rat]
Predicted to enable actin binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; podocyte cell migration; and positive regulation of bleb assembly. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including bleb; midbody; and nucleoplasm. Predicted to be active in actomyosin contractile ring. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anln |
| Official Name | anillin, actin binding protein [Source:RGD Symbol;Acc:1561367] |
| Ensembl ID | ENSRNOG00000014343 |
| Bio databases IDs | |
| Aliases | anillin, actin binding protein |
| Synonyms | 1110037A17Rik, 2900037I21RIK, ANILLIN, anillin, actin binding protein, FSGS8, RGD1561367, scra, Scraps |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell division protein anillin
- Anillin N-terminus
- actin binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the Anln gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- liver cancer
- epithelial cancer
- breast cancer
- non-small cell lung cancer
- prostate cancer
- hepatocellular carcinoma
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- proliferation
- migration
- cell death
- cell viability
- differentiation
- molecular cleavage in
- cytokinesis
- formation
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical rim
- actin cytoskeleton
- cell cortex
- Nucleus
- contractile rings
- midbody
- cytosol
- plasma membrane projections
- nuclear foci
- nucleoplasm
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinesis, actomyosin contractile ring assembly
- cytokinesis after mitosis
- regulation of exit from mitosis
- septin ring assembly
- septin ring organization
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- actomyosin contractile ring
- cell cortex
- actin cytoskeleton
- bleb
- cytosol
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin binding
- cadherin binding